With Alcaraz absent, top seed Sinner could secure his own career Grand Slam – winning each of the major tournaments at least once – with the French Open the only one missing from his collection.
The Italian arrives in Paris in top form, having won the past six ATP Masters 1000 titles – including three consecutive clay-court events at Monte Carlo, Madrid and Rome.
In doing so, he became just the second man, after Novak Djokovic, to complete the full set of nine Masters titles – known as the ‘career Golden Masters’.
Djokovic has won three French Open titles but the 38-year-old has not played many matches this year and suffered an early exit at the Italian Open in his only clay-court appearance this season.
While Sinner is the red-hot favourite in the men’s draw, picking a women’s singles winner is harder to predict.
Reigning champion Gauff reached the final of the Italian Open, where she was defeated by Elina Svitolina, but her form has been inconsistent in 2026.
Barring an injury worry, top seed Sabalenka should be in contention, along with Swiatek – a four-time winner at Roland Garros – and Australian Open champion Elena Rybakina.