INDIANAPOLIS, IN – Despite falling behind 7-0, the San Francisco 49ers raced past the Indianapolis Colts, 48-27, on Monday night at Lucas Oil Stadium.
49ers quarterback Brock Purdy threw for 295 yards and 5 touchdowns, and led San Francisco to its highest scoring game of the season.
Kevin Harlan and Ross Tucker called the action on Westwood One Sports.
𝟑 𝐅𝐢𝐫𝐬𝐭 𝐇𝐚𝐥𝐟 𝐓𝐃 𝐏𝐚𝐬𝐬𝐞𝐬!
Brock Purdy & the 49ers are clicking on all cylinders.
This Purdy to Kittle connection made it 21-14 #FTTB in the middle of the second quarter.
🗣️: Kevin Harlan & @RossTuckerNFL pic.twitter.com/kANR8dvIdK— Westwood One Sports (@westwood1sports) December 23, 2025
𝟱 𝗧𝗗𝘀 𝗳𝗼𝗿 𝗕𝗿𝗼𝗰𝗸 𝗣𝘂𝗿𝗱𝘆!
What a night for the 49ers quarterback in Indy.
Purdy’s 5th score put #FTTB ahead 41-27 in the 4th quarter.
🗣️: Kevin Harlan & @RossTuckerNFL pic.twitter.com/fCp9YOdlbn— Westwood One Sports (@westwood1sports) December 23, 2025