Monday Night Football in Week 14 of the 2025 NFL season is a showdown between the Philadelphia Eagles and Los Angeles Chargers in L.A. Although both teams are 8-4, all is not perfect for either one. Philadelphia is on a two-game losing streak, while Los Angeles is two games behind Denver in the AFC West.
Let’s dive into my Eagles vs. Chargers predictions.
Philadelphia Eagles vs. Los Angeles Chargers odds
Money line: Eagles -140 / Chargers +120
Spread: Eagles -2.5 (-110) / Chargers +2.5 (-110)
Total: Over 41.5 (-110) / Under 41.5 (-110)
Philadelphia Eagles vs. Los Angeles Chargers best bet #1: Chargers +2.5 (-110)
We have seen this story before with the Eagles. Yes, they won the Super Bowl last season — but the 2023 campaign was a total disaster down the stretch. It hasn’t reached quite that level (yet) in 2025, but the parallels are starting to form. Philadelphia has lost two games in a row and the offense has been woeful for an even longer stretch. Prior to this current skid, the Eagles scored a total of 26 points in ugly wins over the Packers and Lions. Quarterback Jalen Hurts has struggled to throw the ball down the field, AJ Brown remains unhappy, and Saquon Barkley just isn’t the Saquon of 2024.
The Chargers have dealt with their own problems on offense, but the offensive line is getting healthier, Justin Herbert (hand injury on his non-throwing side) should be good to go, and rookie running back Omarion Hampton is back for the first time since Week 5. Hampton and company get to face an Eagles defense that got abused by the Bears’ running game on Black Friday. Chicago rushed for 281 yards and amassed 425 total yards of offense during a 24-15 upset victory in Philly. Playing at home game against a reeling opponent that resides three time zones away, the Bolts have a good chance to win this one outright.
Philadelphia Eagles vs. Los Angeles Chargers best player prop bet: Omarion Hampton to score a touchdown (+170)
Hampton is finally back from his ankle injury and will play for the first time since Week 5. Before getting hurt, the 2025 first-round pick had 66 carries for 314 yards and two touchdowns while also racking up 136 receiving yards.
He has every reason to pick up right where he left off considering his favorable matchup on Monday Night Football. Philly’s run defense hasn’t been great all year long and it was especially poor against Chicago in Week 13. The Eagles have given up 14 rushing touchdowns in 2025 — even more than their opponents’ 12 passing TDs. Chargers RB2 Kimani Vidal will probably get a decent amount of touches as Hampton works his way back into game action, but Vidal certainly isn’t a goal-line kind of running back. I expect Hampton to be featured whenever Los Angeles approaches the endzone. +170 is great value.