Germany and Ghana will go head-to-head in a fierce international friendly in Stuttgart on Monday.
The two teams will use the game to fine-tune their preparations for the 2026 FIFA World Cup in North America.
The BlackStars were beaten without recognition by Austria and would be hoping to make amends when they face with Germany.
Germany beat Switzerland 4-3 in a closely knitted game.
Nagelsmann will be hoping to form a fulcrum around Florian Wirtz, Jonathan Tah, Antonio Rüdiger, and Joshua Kimmich in the upcoming game against Ghana, despite the absence of goalkeeper Urbig.
Otto will have to swing a number of chances and hand debuts to Derrick Luckassen and Daniel Agyei, but Marvin Senaya and Patric Pfeiffer will be looking to impress the technical handlers.
He has to go for a more attacking lineup and bench the likes of Jordan and Partey, who have lost their legs in recent months.
The game is set for Monday, 30th March at MHP Arena, Stuttgart, 6:45pm BST
Predicted lineups
Germany: Nubel; Kimmich, Thiaw, Rudiger, Brown; Gnabry, Gross, Stach; Karl, Undav, Schade
Ghana: Ghana: Zigi; Senaya, Pfeiffer, Djiku, Mensah; Yirenkyi, Partey, Issahaku, Semenyo; Adu, Ayew